Both the Nautilus and RX have child safety locks to prevent children from opening the rear doors. The Nautilus has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The RX’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
To help make backing out of a parking space safer, the Nautilus has standard Cross-Traffic Alert with Rear Cross Traffic Braking, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Parking Support Brake costs extra on the RX.
Both the Nautilus and the RX have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available all wheel drive.

